Breakthrough
Long COVID Biomarker Identified by Aethlon Medical (Nasdaq: $AEMD) Opens Door
for Hemopurifier Treatment
(Investorideas.com
Newswire) Investorideas.com, a trusted investment platform for retail investors
reports breaking Medical Tech Stock news for
Aethlon Medical, Inc. (Nasdaq: AEMD),
a clinical-stage medical therapeutic company focused on developing
products to treat cancer and life-threatening viral infections for which there
is no treatment.
Aethlon Medical, Inc. (Nasdaq: AEMD),today announced
publication of new peer-reviewed research in the International Journal of
Molecular Sciences demonstrating that patients with Long COVID exhibit
significantly increased levels of mannosylated extracellular vesicles (EVs)
that can be captured using the same Galanthus nivalis agglutinin (GNA) affinity
resin incorporated into the Company's Hemopurifier®.
Peer-reviewed
study identifies altered extracellular vesicles in Long COVID and provides
additional scientific rationale for evaluating the Hemopurifier® as a potential
treatment
The study, conducted in collaboration with
investigators from the University of California, San Francisco (UCSF), provides
what we believe is new evidence supporting extracellular vesicles as a
potential therapeutic target in Long COVID and helps establish a translational
framework for future studies evaluating whether the Hemopurifier can remove
disease-associated EVs and their molecular cargo.
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"The publication of this study contributes
to the scientific understanding of the biological mechanisms underlying Long
COVID while strengthening the rationale for evaluating the Hemopurifier in this
significant area of unmet medical need," said Jim Frakes, Chief Executive
Officer and Chief Financial Officer of Aethlon Medical. “While the Company’s
current resources and primary focus remain dedicated to advancing our Australian
oncology clinical trial, these findings provide additional translational
evidence supporting future preclinical and clinical studies designed to
determine whether removal of these circulating extracellular vesicles may
benefit patients with Long COVID. More
broadly, we believe these findings reinforce the potential of the Hemopurifier
as a platform technology with potential applications across multiple disease
areas. We believe there exists a
‘pipeline within a single device.’”
Key Findings
Among the study's principal findings:
●
Patients with Long COVID had
approximately two-fold higher levels of mannose-positive extracellular
vesicles than individuals who recovered fully following COVID-19 infection.
●
Small extracellular vesicles carrying
disease-associated glycosylation patterns were successfully captured using GNA
affinity resin, the active binding component of the Hemopurifier.
●
GNA affinity resin treatment
significantly reduced seven circulating microRNAs associated with immune
regulation and inflammatory signaling.
●
Computational pathway analysis suggested
modulation of several biologically relevant signaling pathways implicated in
Long COVID, including JAK-STAT, VEGF, PI3K, and Estrogen signaling.
●
The findings help establish a mechanistic
link between disease-associated extracellular vesicles and the Hemopurifier's
lectin-based capture technology.
The research analyzed plasma samples from
participants enrolled in UCSF's Long-term Impact of Infection with Novel
Coronavirus (LIINC) study.
The full peer-reviewed article, titled "Increased
Mannosylation of Extracellular Vesicles in Long COVID Plasma as a Binding
Target for Galanthus nivalis Agglutinin (GNA) Affinity Resin," appears
in the International Journal of Molecular Sciences at https://www.mdpi.com/1422-0067/27/13/5723
About
Aethlon and the Hemopurifier®
Aethlon Medical is a medical therapeutic company focused on developing
the Hemopurifier, a clinical-stage immunotherapeutic device that is designed to
combat cancer and life-threatening viral infections, and for use in organ
transplantation. In human studies, the Hemopurifier has demonstrated the
removal of life-threatening viruses, and in pre-clinical studies, the
Hemopurifier has demonstrated the removal of harmful EVs from biological fluids,
utilizing its proprietary lectin-based technology. This action has potential
applications in cancer, where EVs may promote immune suppression and
metastasis, and in life-threatening infectious diseases. The Hemopurifier is a
U.S. Food and Drug Administration (FDA) designated Breakthrough Device
indicated for the treatment of individuals with advanced or metastatic cancer
who are either unresponsive to or intolerant of standard of care therapy, and
with cancer types in which EVs have been shown to participate in the
development or severity of the disease. The Hemopurifier also holds an FDA
Breakthrough Device designation and an open Investigational Device Exemption
(IDE) application related to the treatment of life-threatening viruses that are
not addressed with approved therapies.
Additional
information can be found at www.AethlonMedical.com.
Aethlon Medical, Inc. (Nasdaq: AEMD) is a featured biotech
stock on Investorideas.com
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info on AEMD at Investorideas.com Visit: https://www.investorideas.com/CO/AEMD/
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