The Hunt for Virus
Treatments Continues Post Covid-19 (NASDAQ: $AEMD) (NASDAQ: $MRNA) (NYSE: $PFE)
(NASDAQ: $IBRX) (NASDAQ: $ALGS) @moderna_tx @pfizer @ImmunityBio @AligosThera
June
7, 2024 - Investorideas.com,
a go-to investing platform, releases the second of a two-part series looking at
news and developments for the treatment of viruses, featuring Aethlon Medical, Inc. (Nasdaq: AEMD), a medical
therapeutic company focused on developing products to treat cancer and life-threatening
infectious diseases.
The
threat of viruses is back in the news with multiple news sources, including the
Guardian
reporting, ”The World Health Organization (WHO) has said a man’s death in
Mexico was caused by a strain of bird flu called H5N2 that has never before
been found in a human.”
This news is paid advertisement/ news
disseminated on behalf of/issued on behalf of Aethlon Medical Inc.
Read this article
featuring AEMD in full at https://www.investorideas.com/news/2024/biotech/06071Virus-Treatments-Post-Covid-19.asp
The
WHO said Wednesday it wasn’t clear how the person became infected. “Although
the source of exposure to the virus in this case is currently unknown, A (H5N2)
viruses have been reported in poultry in Mexico,” it said in a statement.
Continued: “Scientists
are on alert for changes in the virus that could signal that bird flu is
adapting to spread more easily among humans.
Continued: “But the UN agency said Wednesday said the
current risk of the bird flu virus to the general population in Mexico is low.”
With
global populations and economies still feeling the impact of Covid-19, any
virus threat is going to make headlines.
As
viruses make headlines, companies are seeking solutions and not all are focused
on vaccine development.
Aethlon Medical, Inc. (Nasdaq: AEMD) just recently announced an update on its technology for cancer treatment on its planned phase 1 safety, feasibility and dose-finding clinical trials of its Hemopurifier® in patients with solid tumors who have stable or progressive disease during anti-PD-1 monotherapy treatment, such as Keytruda® or Opdivo®.
The
Aethlon Hemopurifier® technology is designed for the rapid depletion of
cancer-promoting exosomes and circulating viruses. The United States Food and
Drug Administration (FDA) has designated the Hemopurifier® as a “Breakthrough
Device” for the treatment of individuals with advanced or metastatic cancer who
are either unresponsive to or intolerant of standard of care therapy, and with
cancer types in which exosomes have been shown to participate in the
development or severity of the disease; and life-threatening viruses that are
not addressed with approved therapies.
As
reported previously, separate from its current focus on cancer treatment,
Aethlon has investigated the potential for the use of the Hemopurifier®
in viral diseases.
According
to their SEC
filing, “We also believe the Hemopurifier can be part of the broad-spectrum
treatment of life-threatening highly glycosylated, or carbohydrate coated,
viruses that are not addressed with an already approved treatment. In
small-scale or early feasibility human studies, the Hemopurifier has been used
in the past to treat individuals infected with human immunodeficiency virus, or
HIV, hepatitis-C and Ebola.”
“Additionally,
in vitro, the Hemopurifier has been demonstrated to capture Zika virus, Lassa
virus, MERS-CoV, cytomegalovirus, Epstein-Barr virus, Herpes simplex virus,
Chikungunya virus, Dengue virus, West Nile virus, smallpox-related viruses,
H1N1 swine flu virus, H5N1 bird flu virus, Monkeypox virus and the
reconstructed Spanish flu virus of 1918. In several cases, these studies were
conducted in collaboration with leading government or non-government research
institutes.”
Recently,
Zacks
reported that “Vaccine Stocks Rise on Growing Threat of Bird Flu
Infections”
“Shares
of several vaccine makers soared after reports suggest that the Biden
administration is in discussions with Moderna (NASDAQ: MRNA) and Pfizer (NYSE:PFE) to set up a possible
vaccine program aimed at preventing the spread of the H5N1 virus, also known as
bird flu, in humans.”
Continued: “These
reports came to light after the discovery of two cases of H5N1 virus in dairy
farm workers in Texas and Michigan this year. Both these workers experienced
symptoms in the eye after coming into contact with dairy cows infected with the
H5N1 virus.”
But
the treatment of viral diseases has other options including immunotherapy.
ImmunityBio
(NASDAQ: IBRX), a
clinical-stage immunotherapy company, announced
earlier this year the publication of preclinical data in the online issue of
Science, First Release indicating that combination therapy with N-803, an IL-15
superagonist, and broadly neutralizing antibodies may potentially enable the
immune system to manage human immunodeficiency virus (HIV) without the need for
antiretroviral treatment.
From the news: In the
preclinical non-human primate study, researchers led by Dr. James Whitney,
Ph.D. and funded by the National Institutes of Health and the National
Institute of Allergy and Infectious Diseases (NIAID) demonstrated that using
N-803, in combination with broadly neutralizing antibodies (bNAbs), led to
sustained viral control after discontinuation of antiretroviral therapy (ART)
in ART-suppressed rhesus macaques infected with simian-human immunodeficiency
virus AD8 (SHIV-AD8). Treatment with N-803 and bNAbs led to immune activation
and transient viremia, but only limited reductions in the SHIV reservoir. Upon
ART discontinuation, all animals experienced viral rebound, followed by
long-term virus control for up to 10 months in approximately 70% of those
treated with N-803 and bNAbs.
"The
viral reservoir in people with HIV is established within the first few days of
infection and cannot be eliminated by the body’s immune system or currently
available treatments, representing a significant obstacle in curing an
established HIV infection," said James B. Whitney, M.D., Study Author and Researcher
at the Center for Virology and Vaccine Research at Beth Israel Deaconess
Medical Center and Harvard Medical School. "When combined with broadly
neutralizing antibodies, N-803 has the potential to provide viral control
without significant reduction in the viral reservoir, which further suggests
that the complete eradication of this reservoir may not be required to induce
sustained remission after discontinuing antiretroviral therapy."
Taking
another approach to viral diseases, Aligos Therapeutics, Inc. (NASDAQ: ALGS) is a clinical
stage biopharmaceutical company that was founded in 2018 with the mission to
become a world leader in the treatment of liver and viral diseases. Aligos’
strategy is to harness the deep expertise and decades of drug development
experience its team has in liver and viral diseases to discover and develop
potentially best-in-class therapeutics for metabolic dysfunction-associated
steatohepatitis (MASH) and viruses with high unmet medical need such as
hepatitis B and coronaviruses.
The
Company just announced
positive data from six poster presentations at the European Association for the
Study of the Liver (EASL) Congress 2024, being held June 5-8 in Milan, Italy.
From the news: Reported
for the first time were antiviral and safety data in HBeAg-negative CHB
subjects who received a daily single dose of 300 mg ALG-000184 monotherapy for
≤60 weeks. In all 11 subjects (100%), complete suppression of HBV DNA (<LLOQ
10 IU/mL) and RNA (<LLOQ 10 copies/mL) were noted, with reduction in HBcrAg
levels indicating inhibition of HBV replication, as well as inhibition of
cccDNA establishment/replenishment. In both patient populations, ALG-000184
continues to be well tolerated with no viral breakthrough.
With
bird flu cases on the rise, retail investors are once again on the hunt for
stocks with potential solutions.
As
Bloomberg reported
recently,”Mounting cases of bird flu in humans is luring the day trading
crowd to snap up stock in vaccine developers. It’s a familiar setup for
industry veterans who have witnessed past trading frenzies at the first signs
of an outbreak.”
This
won’t be the last viral outbreak. There are more viruses than stars in the
universe. And there are multiple solutions to treating viruses in addition to
vaccines.
Read
part one of the series at Investorideas.com
https://www.investorideas.com/news/2024/biotech/06031Blood-Purification-Medical-Devices.asp
Research biotech and medical device/ tech
stocks at Investorideas.com
https://www.investorideas.com/BIS/Stock_List.asp
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