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Monday, April 14, 2014

Biotech News Alert: Q & A Interview with C.E.O of Sunshine Biopharma (OTCQB: SBFM) Discussing Recent News of Improved Effectiveness of Lead Compound Adva-27a

New York, NY - Point Roberts, WA - April 14, 2014 ( Biotech Newswire), a global news source covering leading sectors including biotech and pharma, issues an exclusive Q&A interview with the CEO of Sunshine Biopharma Inc. ( OTCQB: SBFM ), a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer.

Dr. Steve N. Slilaty, Chief Executive Officer of Sunshine Biopharma shares insights into recent developments with the company’s lead compound, Adva-27a.
The company recently announced improved effectiveness of your lead compound Adva-27a. Can you explain to investors what the results were and what that means moving forward?
A: Dr. Steve N. Slilaty, Chief Executive Officer of Sunshine Biopharma
We resolved the two isomeric forms of our lead anticancer compound, Adva-27a, and as a result the specific activity of the drug candidate has increased 9.5-fold. We had previously announced that the concentration at which Adva-27a inhibited 50% of the activity of Topoisomerase II, an enzyme that cancer cells use to proliferate, (IC50) was 13.7 micromolar (see press release issued on October 5, 2011). As a result of this recent laboratory development Adva-27a’s IC50 has dropped 9.5-fold, to 1.44 micromolar.
This implies that significantly lower quantities of the drug can be used to achieve the same effect. In the long run, this could also mean lower therapeutic dosages for our future breast cancer and pancreatic cancer patients, which theoretically should result in reduced side-effects.
Will this improved effectiveness apply to all the cancers you are targeting or just one specific target?
A: Dr. Steve N. Slilaty, Chief Executive Officer of Sunshine Biopharma
Yes, theoretically this improved effectiveness applies to all cancer types in which Adva-27a is effective.
What triggered you toresolve the two isomeric forms of your lead anticancer compound, Adva-27a?.
A: Dr. Steve N. Slilaty, Chief Executive Officer of Sunshine Biopharma
Resolving the isomeric forms of a lead compound is usually one of the matters addressed at the final stages of drug synthesis. Not all compounds have isomeric forms. Adva-27a happens to be a compound that does, owing to the presence of a carbohydrate moiety which is important for the anticancer activity of the molecule.
You announced in late January that the company is now targeting pancreatic cancer as a second indication for Adva-27a, what is the significance of a second indication?
A: Dr. Steve N. Slilaty, Chief Executive Officer of Sunshine Biopharma
Pancreatic cancer has an extremely poor prognosis. Most pancreatic cancer patients will die within one year of diagnosis. Cancer of the pancreas is the fourth most common cause of cancer-related deaths in the United States. Recently, the Pancreatic Cancer Action Network released a special report entitled, ‘The Alarming Rise of Pancreatic Cancer Deaths in the United States: Why We Need to Stem the Tide Today’. The alarming findings presented in the report included the fact that by the year 2020, and possibly as early as 2015, pancreatic cancer will move from the fourth leading cause of cancer deaths to the second leading cause of cancer deaths in the United States. It is the aggressive nature and lack of effective therapy that lead us to apply Adva-27a for use against pancreatic cancer.
About Adva-27a
Adva-27a is Sunshine Biopharma's lead anticancer compound, a small molecule that has recently been shown to be effective at killing multidrug resistant breast cancer cells, small-cell lung cancer cells, uterine sarcoma cells and pancreatic cancer cells (Published in ANTICANCER RESEARCH, Volume 32, Pages 4423-4432, October 2012). Adva-27a is currently in the IND-Enabling stage of development. The original U.S. patent covering Adva-27a was issued on August 7, 2012 under U.S. patent number 8,236,935.
About Sunshine Biopharma Inc. ( OTCBB: SBFM )
Sunshine Biopharma is an early stage pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer. Sunshine Biopharma recently announced that it has initiated IND-Enabling studies for its lead antitumor compound, Adva-27a, which is currently targeted for multidrug resistant cancer.
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