SAN DIEGO - October 25, 2012 (Investorideas.com newswire) - Aethlon Medical, Inc. (
OTCBB: AEMD),
the pioneer in developing selective therapeutic filtration devices to
address infectious disease, cancer and other life-threatening
conditions, disclosed today that U.S. Patent number 8,288,172 was issued
to the Company by the U.S. Patent and Trademark Office (USPTO) on
October 16th, 2012. The patent entitled "Extracorporeal Removal of
Microvesicular Particles," provides Aethlon Medical the exclusive right
to remove immune suppressive microvesicular particles, which include but
are not limited to exosomes from the circulation of treated patients. A
therapy able to inhibit or reduce the presence of cancer-secreted
exosomes would address a significant unmet medical need in the effort to
combat cancer.
The Aethlon Hemopurifier®, which is a first-in-class medical device
to treat Hepatitis C virus (HCV), has also been validated to capture
exosomes underlying breast cancer, ovarian cancer, metastatic melanoma,
colorectal cancer, and lymphoma during preclinical in vitro studies.
Cancer-secreted exosomes promote tumor progression by inducing
apoptosis or programmed cell death of anti-cancer immune cells. As a
result of inhibiting the immune response, exosomes increase the
proliferation and spread of many forms of cancer. The particles also
promote angiogenesis (essential for tumor survival and growth), increase
tumor aggressiveness, and contribute to anti-cancer drug resistance.
Researchers have recently discovered that cancer-secreted exosomes also
seed the formation and spread of tumor metastasis.
"The issuance of this patent sets the stage for advancing our
Hemopurifier® as an adjunct cancer therapy, and at the same time
restricts the market emergence of other extracorporeal strategies to
address this vital therapeutic target," stated Jim Joyce, Chairman and
CEO at Aethlon Medical.
In addition to granting Aethlon the exclusive right to remove
microvesicular particles (including exosomes), the patent describes a
method to bind and capture immune suppressive microvesicular particles
from blood with a medical filtration device containing single or
multiple affinity agents, which can include antibodies, aptamers, beads,
lectins, proteins, or other compounds that adhere to microvesicles or
exosomes, which are also referred to as epididimosomes, argosomes,
exosome-like vesicles, microparticles, promininosomes, prostasomes,
dexosomes, texosomes, dex, tex, archeosomes and oncosomes.
About Aethlon Medical
The Aethlon Medical mission is to create innovative medical devices
that address unmet medical needs in cancer, infectious disease, and
other life-threatening conditions. Our Aethlon ADAPT™ System is a
revenue-stage technology platform that provides the basis for a new
class of therapeutics that target the selective removal of disease
enabling particles from the entire circulatory system. The Aethlon
ADAPT™ product pipeline includes the Aethlon Hemopurifier® to address
infectious disease and cancer; HER2osome™ to target HER2+ breast cancer,
and a medical device being developed under a contract with DARPA that
would reduce the incidence of sepsis in combat-injured soldiers and
civilians. For more information, please visit
www.aethlonmedical.com.
Certain statements herein may be forward-looking and involve risks
and uncertainties. Such forward-looking statements involve assumptions,
known and unknown risks, uncertainties and other factors which may
cause the actual results, performance or achievements of Aethlon
Medical, Inc. to be materially different from any future results,
performance, or achievements expressed or implied by the forward-looking
statements. Such potential risks and uncertainties include, without
limitation, that the company can successfully protect its intellectual
property, that removal of exosomes from the human body will impact or
lead to successful treatment of cancer, or that exosomes are the cause
of tumor growth and progression, that the FDA will not approve the
initiation of the Company's clinical programs or provide market
clearance of the company's products, future human studies whether
revenue or non-revenue generating of the Aethlon ADAPT™ system or the
Aethlon Hemopurifier® as an adjunct therapy to improve patient
responsiveness to established cancer or hepatitis C therapies or as a
standalone cancer or hepatitis C therapy, the Company's ability to raise
capital when needed, the Company's ability to complete the development
of its planned products, the Company's ability to manufacture its
products either internally or through outside companies and provide its
services, the impact of government regulations, patent protection on the
Company's proprietary technology, product liability exposure,
uncertainty of market acceptance, competition, technological change, and
other risk factors. In such instances, actual results could differ
materially as a result of a variety of factors, including the risks
associated with the effect of changing economic conditions and other
risk factors detailed in the Company's Securities and Exchange
Commission filings. The Company undertakes no obligation to publicly
update or revise any forward-looking statements, whether as a result of
new information, future events, or otherwise.
Contacts:
James A. Joyce
Chairman and CEO
858.459.7800 x301
jj@aethlonmedical.com
Jim Frakes
Chief Financial Officer
858.459.7800 x300
jfrakes@aethlonmedical.com
Marc Robins
877.276.2467
mr@aethlonmedical.com
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