Medical
Therapeutic Stock Aethlon Medical, Inc. (NASDAQ: $AEMD) Gains on Cancer
Clinical Trial update
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news for Aethlon
Medical, Inc.
(Nasdaq: AEMD), a medical therapeutic company focused on
developing products to treat cancer and life-threatening infectious diseases.
Aethlon is trading up today, currently at $0.6930,
up 0.0700, gaining 11.1643% on over 2.1 Million shares. The stock has a day’s
high of $0.75 as of this report.
Aethlon
Medical, Inc.
(Nasdaq: AEMD) today announced a
significant milestone: the treatment of the first patient with the Hemopurifier
in its Australian safety, feasibility and dose-finding clinical trial of the
Hemopurifier. This trial is designed for patients with solid tumors who have
stable or progressive disease during anti-PD-1 monotherapy treatment, such as
Keytruda® (pembrolizumab) or Opdivo® (nivolumab) (AEMD-2022-06 Hemopurifier
Study). The patient was enrolled on October 29, 2024, by Prof. Michael Brown
and his staff at the Cancer Clinical Trials Unit, CALHN, Royal Adelaide
Hospital in Australia, and treated with the Hemopurifer on January 29, 2025, by
Prof. Toby Coates and the dialysis staff.
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The patient treated was determined to
have progressive disease following a two-month "run -in" period of
the anti-PD-1 drug Nivolumab. During this period, serial measurements of
extracellular vesicles (EVs) and anti-tumor T cell activity were obtained. The
patient was then treated with the Aethlon Hemopurifier for 4 hours on a single
day and tolerated the procedure without complications. The patient will have
follow-up safety visits, EV and T cell measurements as well as imaging for
clinical response.
"Treatment of the first patient
represents the achievement of a critical milestone for Aethlon Medical in the
clinical development of the Hemopurifier in Oncology," stated Steven LaRosa,
MD, Chief Medical Officer of Aethlon Medical. "We are excited to receive
the data from this first treatment cohort, anticipating insights into how the
Hemopurifier may reduce tumor-derived extracellular vesicles and enhance T cell
activity against tumors".
Currently, only approximately 30-40%
of patients who receive pembrolizumab or nivolumab will have lasting clinical
responses to these agents. EVs produced by tumors have been implicated in the
spread of cancers as well as the resistance to anti-PD-1 therapies. The Aethlon
Hemopurifier has been designed to bind and remove these EVs from the
bloodstream, which may improve therapeutic response rates to anti-PD-1
antibodies. In preclinical studies, the Hemopurifier has been shown to reduce
the number of exosomes from the plasma of cancer patient samples.
The primary endpoint of the
approximately 18-patient, safety, feasibility, and dose-finding trial is the
incidence of adverse events and clinically significant changes in safety lab
tests of Hemopurifier treated patients with solid tumors with stable or
progressive disease at different treatment intervals, after a two-month run-in
period of PD-1 antibody, Keytruda® or Opdivo® monotherapy. Patients who do not
respond to the therapy will be eligible to enter the Hemopurifier period of the
study where sequential cohorts will receive 1, 2, or 3 Hemopurifier treatments
during a one-week period. In addition to monitoring safety, the study is
designed to examine the number of Hemopurifier treatments needed to decrease
the concentration of EVs and if these changes in EV concentrations improve the
body's own natural ability to attack tumor cells. These exploratory central
laboratory analyses are expected to inform the design of a subsequent efficacy
and safety, Premarket Approval (PMA), study required by regulatory agencies.
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